Parkinson gene partners
نویسندگان
چکیده
منابع مشابه
Identifying Coevolving Partners from Paralogous Gene Families
Many methods have been developed to detect coevolution from aligned sequences. However, all the existing methods require a one-to-one mapping of candidate coevolving partners (nucleotides, amino acids) a priori. When two families of sequences have distinct duplication and loss histories, finding the one-to-one mapping of coevolving partners can be computationally involved. We propose an algorit...
متن کاملAssociation of SHANK3 Gene Polymorphism and Parkinson Disease in the North of Iran
Introduction: Parkinson Disease (PD), the second most common chronic neurodegenerative disorder, is characterized by tremor, bradykinesia, rigidity, and postural instability. SHANK3 (SH3 and multiple ankyrin repeat domain 3) belongs to the extremely conserved ProSAP/ Shank family of synaptic scaffolding proteins. Meanwhile, rs9616915 is a non-synonymous SNP (T>C) located in the exon 6 of the SH...
متن کاملSNCA Gene Multiplication: A Model Mechanism of Parkinson Disease
Parkinson disease (PD) is caused by several pathogenic mutations in genes such as alphasynuclein (SNCA; MIM#163890), Leucine-rich repeat kinase 2 (LRRK2; MIM#609007), PARKIN (parkin; MIM#602544), PTEN-induced kinase 1 (PINK1; MIM#608309), and DJ-1 (MIM#602533) (Farrer, 2006). The alpha-synuclein protein is also a major component of Lewy bodies (LB), the pathologic substrate that is observed in ...
متن کاملGenetic Architecture of MAPT Gene Region in Parkinson Disease Subtypes
The microtubule-associated protein tau (MAPT) region has been conceptualized as a model of the interaction between genetics and functional disease outcomes in neurodegenerative disorders, such as Parkinson disease (PD). Indeed, haplotype-specific differences in expression and alternative splicing of MAPT transcripts affect cellular functions at different levels, increasing susceptibility to a r...
متن کاملGlutamate Receptor Gene GRIN2A, Coffee, and Parkinson Disease
1 Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, New York, United States of America, 2 New England Research Institutes Inc., Watertown, Massachusetts, United States of America, 3 Dr. John T. Macdonald Foundation Department of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, Unite...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Medicine
سال: 2013
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm.3131